Job Description

Job Description

ICR's Regenerative Immunology program is focused on regenerating the aging immune system, the decline of which underlies many of the most devastating age-related diseases. We're hiring a Principal Scientist to lead our Thymic Regeneration Team to restore thymic function and rejuvenate adaptive immunity. You'll need a deep background in immunology, thymic biology and iPSCs.

With ICR, you'll get to:

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• Lead a cutting-edge team developing iPSC-derived thymic epithelial cells (iTECs) and thymic organoids to rejuvenate the aging immune system
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• Contribute highly practical and readily translatable thymic regeneration, immune reconstitution and rejuvenative medicine ideas
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• Design and optimize directed-differentiation protocols to generate functional, TECs from human iPSCs
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• Build, characterize and validate 3D thymic organoids capable of supporting de novo T-cell development
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• Collaborate with other ICR scientists and groups to advance immune rejuvenation under a personalized medicine paradigm
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Please apply if you have:

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• A PhD or MD/PhD
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• At least 10 years of research experience, preferably in thymic biology, stem cell differentiation, organoid engineering or regenerative immunology
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• Current and in-depth knowledge of thymic epithelial cell biology, iPSC directed differentiation, T-cell development and tissue engineering
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Ideally, you'll also have:

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• Expert knowledge of thymic epithelial cell ontogeny, FOXN1 biology, T-cell selection and thymic niche reconstitution
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• Experience with iPSC culture, directed differentiation, 3D organoid culture, single-cell genomics, RNAseq, flow cytometry, immunofluorescent microscopy, CRISPR gene editing and cell culture
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• Experience with in vivo transplantation, humanized mouse models and assessment of functional immune reconstitution
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• Even if you don't meet all of these criteria, please apply anyway
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And you'll need:

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• An easygoing, friendly personality
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• The ability to work in the United States without sponsorship
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If you don't combine your cover letter with your CV or resume when you apply through LinkedIn, after you apply please send your cover letter only to: apply@invitroresearch.com with "Cover [Your name]" as the Subject line.

Position title and compensation are commensurate with experience.

The compensation ranges listed below are starting ranges.

Starting base pay range: $160,000/yr - $215,000/yr

Starting bonus range: $10,000/yr - $20,000/yr

Why join ICR?

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• EXERCISE your intellect in challenging and rewarding science
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• ENTER an career dedicated to a mission that matters to everyone
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• ENGAGE in cutting-edge regenerative medicine research
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• EXCELLENT research environment, salaries and relocation expenses (fully covered!)
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